Norwegian biotech Targovax has raised about €21 million in a private placement as it works to advance prostate cancer vaccine TG01 and other programs against a variety of cancers. The Company's candidate, TG01, is a peptide vaccine that targets mutations in the RAS genes that are associated with cancer, and it is in a phase II clinical trial in pancreatic cancer. Targovax started a Phase 1/2 clinical trial (NCT02261714) in June 2016 to investigate its first-generation vaccine TG01’s potential to treat pancreatic cancer that had returned after surgery. TG01 targets the Ras mutation found in more than 85 percent of pancreatic cancers. TG01 is Targovax’s lead RAS immunotherapy product – a neoantigen therapeutic anti-cancer vaccine targeted at the difficult to treat RAS mutations found in over 90% of pancreatic cancer, 50% of colorectal cancer and 20-30% of all cancers. Initially being tested in the clinic in pancreatic cancer, it is hoped that by inducing mutant RAS specific T-cell immune responses in cancer patients with RAS mutations, TG01 will prolong time to cancer progression, increase survival an… TG01是基于Targovax公司开发的TG多肽输送平台开发的肿瘤免疫疗法药物。 Targovax 公司是一家临床阶段的生物技术公司，专注于开发新型免疫激活剂用于难治性实体瘤的治疗。 近日，该公司公布了 实验性药物TG01 开放标签I/II期临床研究CTTG01-01中32例患者的完整数据集。 2019-5-23 · Oslo, Norway, 23 May 2019 – Targovax ASA (OSE: TRVX), a clinical stage biotechnology company developing immune activators to target hard-to-treat solid tumors, today announces median overall survival of 33.3 months and 38% three-year survival rate in the 32-patient phase I/II clinical trial evaluating TG01 in resected pancreatic cancer in combination with standard of care chemotherapy … Targovax is a clinical stage immuno-oncology company developing immune activators for combination therapy in cancer.

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The vaccine contains 7 mutated RAS peptides, which are injected into the body to induce an immune response. The peptides activate T cells that can attack and destroy the tumor. TG01 is Targovax's lead product candidate from its mutRAS neoantigen cancer vaccine program. The product is an injectable peptide-based immunotherapy designed to treat patients with mutant RAS OSLO, Norway, Jan. 8, 2020 /PRNewswire/ -- Targovax ASA (OSE: TRVX), a clinical stage immuno-oncology company developing oncolytic viruses and cancer vaccines to target hard-to-treat solid tumors, TG01 is Targovax's lead product candidate from its mutRAS neoantigen cancer vaccine program.

These mutations are associated with poor prognosis when present. Targovax AS develops active immunotherapy in the form of cancer vaccines. The lead candidate TG01 is currently in a phase I/II clinical trial in resectable pancreatic cancer. Patients are treated after operation, and the immune system is triggered to recognize cancer specific RAS mutations and kill the cancer cells.

➢ Therapeutic vaccine. ➢ Mimics antigens. 2018年10月17日 Targovax公司是一家临床阶段的生物技术公司，专注于开发新型免疫激活剂用于难 治性实体瘤的治疗。近日，该公司公布了实验性药物TG01开放  9 Oct 2020 Most recently, Targovax developed TG01, a peptide cocktail vaccine that targets 7 peptides mutated in most PDAC tumors, including mutant ras  Targovax and IOVaxis Therapeutics enters Option Agreement for TG mutant RAS IOVaxis buys an exclusive option to license the TG01/02 cancer vaccines for HealthCap V Portfolio Company Targovax Completes NOK 200 Private for the TG platform from a clinical trial of TG01 in resected pancreatic cancer patients  2017年2月7日 生物技术公司Targovax上周迎来了重要时刻。公司开发的用于治疗术后胰腺癌患者 新药TG01临床1/2期数据公布，达到两年生存的受试者超过  Targovax Oy: Helsinki, FI with resected pancreas adenocarcinoma during treatment with TG01/GM-CSF and gemcitabine (CT TG01-01)Annals of Oncology.

The company’s candidate, TG01, is under development to treat pancreatic cancer, one of the most deadly forms of the disease. Targovax ASA: Issuance of restricted stock units (RSUs) to the board members: 17.03. Targovax ASA announces new member of the Board: 17.03. Targovax ASA: Minutes from the Annual General Meeting Targovax / Targovax presentation och paneldiskussion från Redeye Pre-ASCO / Targovax presentation och paneldiskussion från Redeye Pre-ASCO 2018-05-30 15:47 Inför årets stora ASCO-konvent i Chicago, samlades sju av de mest intressanta bolagen på den nordiska cancer-arenan. Oslo, Norway, 6 June 2017: Targovax ASA ("Targovax" or "the Company"; OSE: TRVX), a clinical stage company focused on developing immuno-oncology therapies to target treatment-resistant solid tumors, today announces that it presented clinical data from the phase I/II clinical trial evaluating TG01 in resected pancreatic cancer in a poster presentation at the American Society of Clinical targovax ned 20% i oslo, avslutar studier med tg01 (direkt) 2018-06-12 14:03 Enligt Targovax är det inte tidsmässigt eller ekonomiskt försvarbart att föra kandidaten TG01 vidare då en konkurrerande studie Prodige 24/CCTG PA.6 har visat på ordentligt förbättrad överlevnad. Targovax Strengthens 2-year Survival Rate in Resected Pancreatic Cancer With TG01 Median overall survival was 33.4 months compared to 27.6 months in the ESPAC4 trial TG01 is Targovax's first product to arise from its TG-Peptide platform. The platform yields injectable peptide-based onco-immunotherapies that are designed to treat patients whose tumors express RAS mutations.
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This extends the IP protection of TG01 and TG02 into 2034 In February 2019 , Targovax announced that the first patient has been treated in the dose expansion cohort of the ONCOS-102 trial in melanoma Most Read. InSilicoTrials: accelerating the uptake of simulation in clinical research; Biogen’s Spinraza set to increase its chances to maintain a strong position in spinal muscular atrophy OS and DFS was encouraging in view of published reports. TG01/GM-CSF generated early immune responses in 89% of patients with R0/R1 resected pancreatic cancer. 13 pts have been recruited in a modified dose cohort with 2 yrs data in 2Q 2018. Clinical trial identification.

➢ Mimics antigens. 2018年10月17日 Targovax公司是一家临床阶段的生物技术公司，专注于开发新型免疫激活剂用于难 治性实体瘤的治疗。近日，该公司公布了实验性药物TG01开放  9 Oct 2020 Most recently, Targovax developed TG01, a peptide cocktail vaccine that targets 7 peptides mutated in most PDAC tumors, including mutant ras  Targovax and IOVaxis Therapeutics enters Option Agreement for TG mutant RAS IOVaxis buys an exclusive option to license the TG01/02 cancer vaccines for HealthCap V Portfolio Company Targovax Completes NOK 200 Private for the TG platform from a clinical trial of TG01 in resected pancreatic cancer patients  2017年2月7日 生物技术公司Targovax上周迎来了重要时刻。公司开发的用于治疗术后胰腺癌患者 新药TG01临床1/2期数据公布，达到两年生存的受试者超过  Targovax Oy: Helsinki, FI with resected pancreas adenocarcinoma during treatment with TG01/GM-CSF and gemcitabine (CT TG01-01)Annals of Oncology.
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Read our disclaimer for details. Targovax takes TG01 immunotherapy targeting RAS mutations inT pancreatic cancer into Phase IIa trials in UK. Contacts. Media Richard Hayhurst cell phone: +44 7711 821 527 E-mail: The milestone payment for the exercise of the option to license TG01/02 is USD 3 million. Under the Option Agreement, IOVaxis and Targovax will jointly define a development plan in the territory, With evidence of the potential and limitations of checkpoint inhibitors mounting, Targovax is pitching TG01 and particularly ONCOS-102 as ways to boost the proportion of patients who respond to Targovax started a Phase 1/2 clinical trial (NCT02261714) in June 2016 to investigate its first-generation vaccine TG01’s potential to treat pancreatic cancer that had returned after surgery. TG01 targets the Ras mutation found in more than 85 percent of pancreatic cancers. Targovax is also developing a neo-antigen cancer vaccine targeting tumors that express mutated forms of RAS. The TG vaccine program has shown a signal of efficacy in a 32-patient trial with TG01 in TG01 (Targovax ASA, Oslo, Norway) is the first injectable antigen-specific cancer immunotherapy (ASCI) targeted to treat patients with Kirsten rat sarcoma viral oncogene homolog (KRAS) mutations.

Under the Option Agreement, IOVaxis and Targovax will jointly define a development plan in the territory, With evidence of the potential and limitations of checkpoint inhibitors mounting, Targovax is pitching TG01 and particularly ONCOS-102 as ways to boost the proportion of patients who respond to Targovax started a Phase 1/2 clinical trial (NCT02261714) in June 2016 to investigate its first-generation vaccine TG01’s potential to treat pancreatic cancer that had returned after surgery.

Earlier studies demonstrate that adjuvant vaccination with TG01/GM-CSF given as monotherapy to pancreatic cancer patients after tumor resection induce immune response in 100% of patients. About Targovax Arming the patient's immune system to fight cancer OSLO, Norway, 24 May 2018 /PRNewswire/ --Targovax ASA ("Targovax" or "the Company") (OSE: TRVX), a clinical stage company focused on developing immuno-oncology therapies to target solid tumors, today announces the completion of the 32-patient phase I/II clinical trial evaluating TG01 in resected pancreatic cancer in combination with standard of care chemotherapy (gemcitabine).